Journal
MARINE DRUGS
Volume 7, Issue 1, Pages 1-8Publisher
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
DOI: 10.3390/md7010001
Keywords
Marine sponge; Aaptos aaptos; aaptaminoids; alkaloids; cytotoxicity
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Funding
- Ministry of Science, Technology and Innovation (MOSTI)
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In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
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