Journal
MAMMALIAN GENOME
Volume 20, Issue 5, Pages 261-268Publisher
SPRINGER
DOI: 10.1007/s00335-009-9186-5
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Funding
- DWT [U01CA105417, P50CA 106991, R01CA092479]
- Lineberger Cancer Center [P30CA016086]
- Center for Gastrointestinal Biology and Disease [P30DK34987]
- NATIONAL CANCER INSTITUTE [R01CA092479, P50CA106991, U01CA105417, P30CA016086, R01CA079869] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK034987] Funding Source: NIH RePORTER
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Colorectal cancer is one of the most prevalent cancers of humans. To experimentally investigate this common disease, numerous murine models have been established. These models accurately recapitulate the molecular and pathologic characteristics of human colorectal cancers, including activation of the myelocytomatosis oncogene (MYC), which has recently been suggested to be a key mediator of colorectal cancer development. This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of colorectal cancer.
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