Journal
MAMMALIAN GENOME
Volume 20, Issue 6, Pages 327-338Publisher
SPRINGER
DOI: 10.1007/s00335-009-9187-4
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Funding
- Cancer Research-UK
- Wellcome Trust
- Medical Research Council - UK
- Wellcome Trust Sanger Institute
- MRC [G0800024] Funding Source: UKRI
- Medical Research Council [G0800024] Funding Source: researchfish
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Next-generation sequencing technologies are revolutionizing biology by allowing for genome-wide transcription factor binding-site profiling, transcriptome sequencing, and more recently, whole-genome resequencing. While it is currently not possible to generate complete de novo assemblies of higher-vertebrate genomes using next-generation sequencing, improvements in sequence read lengths and throughput, coupled with new assembly algorithms for large data sets, will soon make this a reality. These developments will in turn spawn a revolution in how genomic data are used to understand genetics and how model organisms are used for disease gene discovery. This review provides an overview of the current next-generation sequencing platforms and the newest computational tools for the analysis of next-generation sequencing data. We also describe how next-generation sequencing may be applied in the context of vertebrate model organism genetics.
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