Journal
MALARIA JOURNAL
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1475-2875-7-238
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Funding
- NIH [R01 CA102667, K08 AI 51565]
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Background: The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. Methods: Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. Results: There was a significant decrease in CD19(+) B lymphocytes during acute malaria. Characterization of the CD19(+) B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD(+) B cells while there was an increase in CD38(+) IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10(+) CD19(+) B cells in children following an episode of acute malaria with up to 25% of total CD19(+) B cell pool residing in this subset. Conclusion: Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.
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