Journal
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Volume 23, Issue 1, Pages 1-21Publisher
SPRINGER
DOI: 10.1007/s10334-009-0190-2
Keywords
Perfusion; Cerebral blood flow; Dynamic susceptibility contrast MRI; Arterial input function; Quantification
Funding
- Swedish Research Council [13514, 2005-6910, 2007-3974, 2007-6079]
- Crafoord foundation
- Lund University Hospital Donation Funds
- Swedish Cancer Society [2006/1272]
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Absolute quantification of cerebral blood flow, cerebral blood volume and mean transit time is desirable in the determination of tissue viability thresholds and tissue at risk in acute ischaemic stroke, as well as in cases where a global reduction in cerebral blood flow is expected, for example, in patients with dementia or depressive disorders. Absolute values are also useful when comparing sequential examinations of tissue perfusion parameters, for example, in the monitoring and follow-up of various kinds of therapy. Regardless of the method employed, a number of assumptions and approximations must be made to obtain absolute measures of perfusion. Furthermore, the different stages of data acquisition and processing are associated with various degrees of uncertainty. In this review, the problems of particular relevance to absolute quantification of cerebral perfusion parameters using dynamic susceptibility contrast magnetic resonance imaging are discussed, and possible solutions are outlined.
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