Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 81, Issue 1, Pages 220-233Publisher
WILEY
DOI: 10.1002/mrm.27374
Keywords
heart; high spatial resolution; infarction; KWIC filter; radial imaging; T-2 mapping
Funding
- Swiss Heart Foundation
- Swiss National Science Foundation [PZ00P3-154719, 32003B_159727]
- Centre d'Imagerie BioMedicale of the University of Lausanne, University of Geneva, Geneva University Hospitals, Lausanne University Hospital, and Ecole Polytechnique Federale de Lausanne
- Leenaards and Jeantet Foundations
- Swiss National Science Foundation (SNF) [PZ00P3_154719, 32003B_159727] Funding Source: Swiss National Science Foundation (SNF)
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Purpose: To develop high-spatial-resolution cardiac T-2 mapping that allows for a reduced acquisition time while maintaining its precision. We implemented and optimized a new golden-angle radial T-2 mapping technique named SKRATCH (Shared k-space Radial T-2 Characterization of the Heart) that shares k-space peripheries of T-2-weighted images while preserving their contrasts. Methods: Six SKRATCH variants (gradient-recalled echo and balanced SSFP, free-breathing and breath-held, with and without a saturation preparation) were implemented, and their precision was compared with a navigator-gated reference technique in phantoms and 22 healthy volunteers at 3 T. The optimal breath-held SKRATCH technique was applied in a small cohort of patients with subacute myocardial infarction. Results: The faster free-breathing SKRATCH technique reduced the acquisition time by 52.4%, while maintaining the precision and spatial resolution of the reference technique. Similarly, the most precise and robust breath-held SKRATCH technique demonstrated homogenous T-2 values that did not significantly differ from the navigator-gated reference (T-2 = 39.9 +/- 3.4 ms versus 39.5 +/- 3.4 ms, P > .20, respectively). All infarct patients demonstrated a large T-2 elevation in the ischemic regions of the myocardium. Conclusion: The optimized SKRATCH technique enabled the accelerated acquisition of high-spatial-resolution T-2 maps, was validated in healthy adult volunteers, and was successfully applied to a small initial group of patients.
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