Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 73, Issue 5, Pages 1864-1871Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.25317
Keywords
4D flow; ultrahigh field; 7t; aorta; blood flow
Funding
- Medical Research Council
- British Heart Foundation
- NIHR Oxford Biomedical Research Centre Program
- British Heart Foundation [FS/10/43/28415] Funding Source: researchfish
- Medical Research Council [G0900883] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10005] Funding Source: researchfish
- MRC [G0900883] Funding Source: UKRI
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PurposeTo investigate for the first time the feasibility of aortic four-dimensional (4D) flow at 7T, both contrast enhanced (CE) and non-CE. To quantify the signal-to-noise ratio (SNR) in aortic 4D flow as a function of field strength and CE with gadobenate dimeglumine (MultiHance). MethodsSix healthy male volunteers were scanned at 1.5T, 3T, and 7T with both non-CE and CE acquisitions. Temporal SNR was calculated. Flip angle optimization for CE 4D flow was carried out using Bloch simulations that were validated against in vivo measurements. ResultsThe 7T provided 2.2 times the SNR of 3T while 3T provided 1.7 times the SNR of 1.5T in non-CE acquisitions in the descending aorta. The SNR gains achieved by CE were 1.8-fold at 1.5T, 1.7-fold at 3T, and 1.4-fold at 7T, respectively. ConclusionThe 7T provides a new tool to explore aortic 4D flow, yielding higher SNR that can be used to push the boundaries of acceleration and resolution. Field strength and contrast enhancement at all fields provide significant improvements in SNR. Magn Reson Med 73:1864-1871, 2015. (c) 2014 Wiley Periodicals, Inc.
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