Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 70, Issue 2, Pages 454-465Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.24488
Keywords
cardiovascular magnetic resonance imaging; prospective navigators; cardiac diffusion tensor imaging; cardiac diffusion-weighted imaging
Funding
- NIHR Cardiovascular Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London
- National Institutes of Health [R01HL093038]
Ask authors/readers for more resources
The aim of this study was to implement a quantitative in vivo cardiac diffusion tensor imaging (DTI) technique that was robust, reproducible, and feasible to perform in patients with cardiovascular disease. A stimulated-echo single-shot echo-planar imaging (EPI) sequence with zonal excitation and parallel imaging was implemented, together with a novel modification of the prospective navigator (NAV) technique combined with a biofeedback mechanism. Ten volunteers were scanned on two different days, each time with both multiple breath-hold (MBH) and NAV multislice protocols. Fractional anisotropy (FA), mean diffusivity (MD), and helix angle (HA) fiber maps were created. Comparison of initial and repeat scans showed good reproducibility for both MBH and NAV techniques for FA (P > 0.22), MD (P > 0.15), and HA (P > 0.28). Comparison of MBH and NAV FA (FA(MBHday1) = 0.60 +/- 0.04, FA(NAVday1) = 0.60 +/- 0.03, P = 0.57) and MD (MDMBHday1 = 0.8 +/- 0.2 x 10(-3) mm(2)/s, MDNAVday1 = 0.9 +/- 0.2 x 10(-3) mm(2)/s, P = 0.07) values showed no significant differences, while HA values (HA(MBHday1Endo) = 22 +/- 10 degrees, HA(MBHday1Mid-Endo) = 20 +/- 6 degrees, HA(MBHday1Mid-Epi) = -1 +/- 6 degrees, HA(MBHday1Epi) = -17 +/- 6 degrees, HA(NAVday1Endo) = 7 +/- 7 degrees, HA(NAVday1Mid-Endo) = 13 +/- 8 degrees, HA(NAVday1Mid-Epi) = -2 +/- 7 degrees, HA(NAVday1Epi) = -14 +/- 6 degrees) were significantly different. The scan duration was 20% longer with the NAV approach. Currently, the MBH approach is the more robust in normal volunteers. While the NAV technique still requires resolution of some bulk motion sensitivity issues, these preliminary experiments show its potential for in vivo clinical cardiac diffusion tensor imaging and for delivering high-resolution in vivo 3D DTI tractography of the heart. Magn Reson Med 70:454-465, 2013. (c) 2012 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available