Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 69, Issue 1, Pages 62-70Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.24228
Keywords
MR thermometry; T-1 measurement; proton resonance frequency; fat; high-intensity-focused ultrasound
Funding
- Focused Ultrasound Surgery Foundation
- Ben B. and Iris M. Margolis Foundation
- Mark H. Huntsman chair
- NIH [R01 CA134599]
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Thermal therapy procedures being carried out under MR guidance would be safer if temperature changes could be accurately monitored in both water-based and fat-based tissues. To this end, we present a hybrid proton resonance frequency (PRF)/T1 approach for simultaneously measuring PRF shift temperatures in water-based tissues and T1 changes in fat-based tissues. The hybrid PRF/T1 sequence is a standard radiofrequency spoiled gradient echo sequence executed in a dynamic mode with two flip angles alternating every time frame. The PRF information is extracted every time frame using the image phase in the standard approach, and the T1 information is extracted every two time frames using a variable flip angle approach. Simulation studies, ex vivo high intensity focused ultrasound heating experiments, and in vivo stability experiments were performed to test the feasibility of the approach. The results indicate that the hybrid PRF/T1 approach provides PRF temperature maps of the same quality as those obtained by traditional PRF methods while simultaneously being able to track T1 changes in fat-based tissues. Although several potential error sources exist for the T1 measurements, the approach is a promising start toward realizing quantitative temperature measurements in both water-based and fat-based tissues. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.
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