Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 68, Issue 4, Pages 1018-1025Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.24131
Keywords
-aminobutyric acid; MEGA-sLASER; spectral editing; 7 T
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At high field (7 T) spectral editing of ?-aminobutyric acid with MEGA-point-resolved spectroscopy is inefficient due to the large chemical shift displacement error. In this article, a new pulse sequence is designed which has minimal chemical shift displacement error to perform an efficient spectral editing of the ?-aminobutyric acid 3.0 ppm resonance at 7 T. The sequence consists of the conventional MEGA editing pulses and a semi-localized by adiabatic selective refocusing sequence. Phantom and in vivo measurements demonstrated an efficient detection of ?-aminobutyric acid. Using ECG triggering, excellent in vivo performance of the MEGA-semi-localized by adiabatic selective refocusing (MEGA-sLASER) provided well-resolved ?-aminobutyric acid signals in 27 mL volumes in the human brain at an echo time of 74 ms within a relatively short acquisition time (5 min). Furthermore, the high efficiency of the MEGA-sLASER was demonstrated by acquiring small volumes (8 mL) at an echo time of 74 ms, as well as long echo time measurements (222 ms in 27 mL volume). Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.
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