Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 67, Issue 3, Pages 669-678Publisher
WILEY
DOI: 10.1002/mrm.23050
Keywords
cerebral metabolic rate of oxygen; cerebral venous oxygen saturation; cerebral blood flow; MR susceptometry
Funding
- NIH [T90-DA022759, T32-GM07753, R01-EB007942]
- Siemens Healthcare
- Siemens Healthcare, Siemens-MIT Alliance
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Venous oxygen saturation (Yv) in cerebral veins and the cerebral metabolic rate of oxygen (CMRO2) are important indicators for brain function and disease. Although MRI has been used for global measurements of these parameters, currently there is no recognized technique to quantify regional Yv and CMRO2 using noninvasive imaging. This article proposes a technique to quantify CMRO2 from independent MRI estimates of Yv and cerebral blood flow. The approach uses standard gradient-echo and arterial spin labeling acquisitions to make these measurements. Using MR susceptometry on gradient-echo phase images, Yv was quantified for candidate vein segments in gray matter that approximate a long cylinder parallel to the main magnetic field. Local cerebral blood flow for the identified vessel was determined from a corresponding region in the arterial spin labeling perfusion map. Fick's principle of arteriovenous difference was then used to quantify CMRO2 locally around each vessel. Application of this method in young, healthy subjects provided gray matter averages of 59.6% +/- 2.3% for Yv, 51.7 +/- 6.4 mL/100 g/min for cerebral blood flow, and 158 +/- 18 mu ol/100 g/min for CMRO2 (mean +/- SD, n = 12), which is consistent with values previously reported by positron emission tomography and MRI. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.
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