Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 66, Issue 1, Pages 73-81Publisher
WILEY
DOI: 10.1002/mrm.22780
Keywords
functional magnetic resonance imaging; fMRI; EPI; motion correction; prospective; real-time; active marker; device tracking; RF-coil; microcoil; geometric distortion
Funding
- NIH [R21EB006877]
- NIH/NCRR [UL1RR024156]
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Head motion is a fundamental problem in functional magnetic resonance imaging and is often a limiting factor in its clinical implementation. This work presents a rigid-body motion correction strategy for echo-planar imaging sequences that uses micro radiofrequency coil active markers' for real-time, slice-by-slice prospective correction. Before the acquisition of each echo-planar imaging-slice, a short tracking pulse-sequence measures the positions of three active markers integrated into a headband worn by the subject; the rigid-body transformation that realigns these markers to their initial positions is then fed back to dynamically update the scan-plane, maintaining it at a fixed orientation relative to the head. Using this method, prospectively-corrected echo-planar imaging time series are acquired on volunteers performing in-plane and through-plane head motions, with results demonstrating increased image stability over conventional retrospective image-realignment. The benefit of this improved image stability is assessed in a blood oxygenation level dependent functional magnetic resonance imaging application. Finally, a non-rigid-body distortion-correction algorithm is introduced to reduce the remaining signal variation. Magn Reson Med 66:73-81, 2011. (C) 2011 Wiley-Liss, Inc.
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