Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 67, Issue 4, Pages 979-990Publisher
WILEY
DOI: 10.1002/mrm.23074
Keywords
chemical exchange saturation transfer; magnetization transfer; pulsed CEST
Funding
- Ontario Institute for Cancer Research
- Canadian Institute for Health Research
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Phantom experiments in agar and ammonium chloride were performed to evaluate a three-pool model of magnetization transfer and chemical exchange saturation transfer (CEST) in a pulsed saturation transfer experiment. The utility of the pulsed CEST method was demonstrated by varying the pH of the phantoms and observing the effect upon the CEST spectra both with and without the solid agar (the magnetization transfer pool), while fitting the spectra to the Bloch equation model with exchange. Pulsed CEST could be used to robustly quantify parameters related to CEST, including the exchange rate constant describing proton exchange with free water and the concentration of exchanging protons. Furthermore, the exchange rate constant and the CEST pool offset frequency of the ammonium chloride remained unchanged in the presence of a magnetization transfer pool. The logarithm of the fitted exchange rate constant was linearly related to pH: this relationship was maintained in the presence of magnetization transfer. Magn Reson Med 67:979-990, 2012. (c) 2011 Wiley Periodicals, Inc.
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