Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 68, Issue 2, Pages 588-594Publisher
WILEY
DOI: 10.1002/mrm.23250
Keywords
MRI; CEST; saturation pulse; cartilage; GAG; gagCEST
Funding
- NIH-NCRR [P41RR002305]
- NIAMS [NIH-R01AR45404, NIH-R01AR051041]
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The sensitivity of chemical exchange saturation transfer (CEST) on glycosaminoglycans (GAGs) in human knee cartilage (gagCEST) in vivo was evaluated at 3 and 7 T field strengths. Calculated gagCEST values without accounting for B0 inhomogeneity (similar to 0.6 ppm) were >20%. After B0 inhomogeneity correction, calculated gagCEST values were negligible at 3 T and similar to 6% at 7 T. These results suggest that accurate B0 correction is a prerequisite for observing reliable gagCEST. Results obtained with varying saturation pulse durations and amplitudes as well as the consistency between numerical simulations and our experimental results indicate that the negligible gagCEST observed at 3 T is due to direct saturation effects and fast exchange rate. As GAG loss from cartilage is expected to result in a further reduction in gagCEST, gagCEST method is not expected to be clinically useful at 3 T. At high fields such as 7 T, this method holds promise as a viable clinical technique. Magn Reson Med, 2012. (C) 2011 Wiley Periodicals, Inc.
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