Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 68, Issue 1, Pages 30-40Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.23195
Keywords
spin-echo EPI; gradient-echo EPI; multiecho acquisition; dynamic susceptibility-weighted perfusion-weighted imaging; SAGE PWI
Funding
- National Institute of Health [R01EB002711, R01NS047607, R01NS034866, R01NS066506, P41RR009784]
- Lucas Foundation
- Oak Foundation
Ask authors/readers for more resources
In this study, a spin- and gradient-echo echo-planar imaging (SAGE EPI) MRI pulse sequence is presented that allows simultaneous measurements of gradient-echo and spin-echo dynamic susceptibility-contrast perfusion-weighted imaging data. Following signal excitation, five readout trains were acquired using spin- and gradient-echo echo-planar imaging, all of them with echo times of less than 100 ms. Contrast agent concentrations in brain tissue were determined based on absolute R?2* and R2 estimates rather than relative changes in the signals of individual echo trains, producing T1-independent dynamic susceptibility-contrast perfusion-weighted imaging data. Moreover, this acquisition technique enabled vessel size imaging through the simultaneous quantification of R?2* and R2, without an increase in acquisition time. In this work, the concepts of SAGE EPI pulse sequence and results in stroke and tumor imaging are presented. Overall, SAGE EPI combined the advantages of higher sensitivity to contrast agent passage of gradient-echo perfusion-weighted imaging with better microvascular selectivity of spin-echo perfusion-weighted imaging. Magn Reson Med, 2012. (C) 2011 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available