Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 67, Issue 4, Pages 1154-1158Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.23082
Keywords
ultra high-resolution MRI; high field; MRI contrast agents; T1 and T2 contrast; manganese; MEMRI; photoreceptors
Funding
- NIH/NEI [R01 EY014211, EY018855, R01EY09702]
- Department of Veterans Affairs
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3D-MR microscopy at 11.7T and 20 x 20 x 57 mu m resolution was performed on formalin-fixed rat eyes with: (I) no contrast agent and (II) Gadodiamide (Omniscan (R)) added to the fixative. Group I data showed generally poor contrast among layers. Group II data showed markedly better lamina-specific contrast with the nerve fiber + ganglion cell layer and inner nuclear layer being hypointense, and the inner plexiform, outer plexiform, outer nuclear layer, and the segments being hyperintense. The signal-to-noise ratio in group II was higher than group I, consistent with Gadodiamide acting as a T1-contrast agent. All major retinal layers were assigned and their thicknesses quantified with corroboration by histology. MR microscopy allows nondestructive examination of valuable specimens and could have applications in disease and in vivo. Magn Reson Med, 2011. (C) 2011 Wiley Periodicals, Inc.
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