Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 65, Issue 3, Pages 620-626Publisher
WILEY
DOI: 10.1002/mrm.22737
Keywords
lung morphometry; mouse; hyperpolarized He-3; diffusion; alveolar size
Funding
- NIH (Alafi Neuroimaging Laboratory, Hope Center for Neurological Disorders) [R01 HL090806, R01 HL7003701, P30 NS057105]
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Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based He-3 lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of acinar airways. In this study, the He-3 lung morphometry technique is successfully implemented for in vivo studies of mice. Results indicate excellent agreement between in vivo morphometry via He-3 MRI and microscopic morphometry after sacrifice. This opens up new avenues for application of the technique as a precise, noninvasive, in vivo biomarker of changes in lung microstructure, within various mouse models of lung disease. Magn Reson Med 65:620-626, 2011. (c) 2010 Wiley-Liss, Inc.
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