Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 65, Issue 2, Pages 313-319Publisher
WILEY
DOI: 10.1002/mrm.22622
Keywords
brown adipose tissue; white adipose tissue; intermolecular zero-quantum coherences
Funding
- NIH [R01-EB2122]
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Brown adipose tissue and white adipose tissue depots are non-invasively characterized in vitro and in vivo in healthy and obese mice using intermolecular zero-quantum coherence transitions between lipid and water spins. Intermolecular zero-quantum coherences enable selective detection of spatial correlation between water and lipid spins and thereby the hydration of fatty deposits with subvoxel resolution. At about a 100 mm distance scale, the major observed peaks are between water, methylene protons at 1.3 ppm, and olefinic protons at 5.3 ppm. Our in vitro results show that the methylene-olefinic intermolecular zero-quantum coherence signal is strong both in brown and white adipose tissues, but that the water-methylene intermolecular zero-quantum coherence signal is characteristic only of brown adipose tissue. In vivo, the ratio of these peaks is substantially higher in lean or young mice than in old or obese mice. Magn Reson Med 65:313-319, 2011. (C) 2010 Wiley-Liss, Inc.
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