Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 64, Issue 3, Pages 672-679Publisher
WILEY
DOI: 10.1002/mrm.22448
Keywords
MR spectroscopy; brain; metabolism; motion
Funding
- NIH [1R01 DA021146, U54 56883, K02-DA16991, G12 RR003061-21]
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Head motion during H-1 MR spectroscopy acquisitions may compromise the quality and reliability of in vivo metabolite measurements. Therefore, a three-plane image-based motion-tracking module was integrated into a single-voxel H-1 MR spectroscopy (point-resolved spectroscopy) sequence. A series of three orthogonal spiral navigator images was acquired immediately prior to the MR spectroscopy water suppression module in order to estimate head motion. By applying the appropriate rotations and translations, the MR spectroscopy voxel position can be updated such that it remains stationary with respect to the brain. Frequency and phase corrections were applied during postprocessing to reduce line width and restore coherent averaging. Spectra acquired during intentional head motion in 11 volunteers demonstrate reduced lipid contamination and increased spectral reproducibility when motion correction is applied. Magn Reson Med 64:672-679, 2010. (C) 2010 Wiley-Liss, Inc.
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