Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 62, Issue 5, Pages 1270-1281Publisher
WILEY
DOI: 10.1002/mrm.22136
Keywords
dynamic contrast-enhanced MRI; T-1-weighted MRI; brain perfusion; blood brain barrier; brain blood volume; brain tumor
Funding
- The Memorial Grant of Merchant Sigurd Abrahamson and Wife Addie Abrahamson
- Lundbeck Foundation
Ask authors/readers for more resources
Assessment of vascular properties is essential to diagnosis and follow-up and basic understanding of pathogenesis in brain tumors. In this study, a procedure is presented that allows concurrent estimation of cerebral perfusion, blood volume, and blood-brain permeability from dynamic T-1-weighted imaging of a bolus of a paramagnetic contrast agent passing through the brain. The methods are applied in patients with brain tumors and in healthy subjects. Perfusion was estimated by model-free deconvolution using Tikhonov's method (gray matter/white matter/tumor: 72 +/- 16/30 8/56 +/- 45 mL/100 g/min); blood volume (6 +/- 2/4 in 6 mL/100 g) and permeability (0.9 +/- 0.4/0.8 +/- 0.3/3 5 mL/100 g/min) were estimated by using Patlak's method and a two-compartment model. A corroboration of these results was achieved by using model simulation. In addition, it was possible to generate maps on a pixel-by-pixel basis of cerebral perfusion, cerebral blood volume, and blood-brain barrier permeability. Magn Reson Med 62:1270-1281, 2009. (C) 2009 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available