Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 62, Issue 6, Pages 1641-1645Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.22160
Keywords
metabolic modeling; TCA cycle; (13)C label; glucose transport; glycemia
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(13)C NMR spectroscopy is a unique tool to measure the cerebral tricarboxylic acid (TCA) cycle rate in vivo. The measurement relies on metabolic modeling of glutamate C3 and C4 enrichment time courses during a (13)C-glucose intravenous infusion. Usual metabolic models require the plasma glucose and (13)C-glucose time courses as input functions, as well as the knowledge of Michaelis-Menten kinetics parameters governing passage through the blood-brain barrier. It is shown in the present work that, when using an infusion protocol yielding a rapidly stable plasma glucose fractional enrichment, metabolic modeling can be simplified in such a manner that this additional information on input function and glucose transport is no longer required, significantly simplifying the measurement of cerebral TCA cycle rate in vivo. Magn Reson Med 62:1641-1645, 2009. (C) 2009 Wiley-Liss, Inc.
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