Journal
MAGNETIC RESONANCE IN CHEMISTRY
Volume 50, Issue 3, Pages 187-192Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrc.2865
Keywords
NMR; 1H; metabonomics; depression; urine; CUMS
Funding
- National Natural Science Foundation of China [81102833]
- Programs of International Science and Technology Cooperation of China [S2012ZR0254]
- special funds for talent introduction for Shanxi Province
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Chronic unpredictable mild stress (CUMS) is a well-validated model of depression. In this study, a urinary metabonomics method based on the NMR spectrometry was used to study the metabolic perturbation in CUMS-induced rat depression model. With pattern recognition analysis, a clear separation of CUMS rats and healthy controls was achieved, and nine endogenous metabolites contributing to the separation were identified. CUMS-treated rats were characterized by the increase of glycine, pyruvate, glutamine, and asparagines, as well as the decrease of 2-oxoglutarate, dimethylglycine, citrate, succinate, and acetate. The urinary biochemical changes related to the metabolic disturbance in CUMS induced depression, and the possible correlations with live qi stagnation in traditional Chinese medicine are discussed. The work shows that CUMS is a reliable model for studying depression, and the noninvasive urinary metabolomic method is a valuable tool to investigate the biochemical pertubations in depression as an early diagnostic means. Copyright (C) 2012 John Wiley & Sons, Ltd.
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