Journal
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA
Volume 17, Issue 2, Pages 277-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mric.2009.01.007
Keywords
Dynamic contrast-enhanced MR imaging; Perfusion; Physics; Oncology
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Quantitative analysis of dynamic contrast-enhanced MR imaging (DCE-MR imaging) has the power to provide information regarding physiologic characteristics of the microvasculature and is, therefore, of great potential value to the practice of oncology. In particular, these techniques could have a significant impact on the development of novel anticancer therapies as a promising biomarker of drug activity. Standardization of DCE-MR imaging acquisition and analysis to provide more reproducible measures of tumor vessel physiology is of crucial importance to realize this potential. The purpose of this article is to review the pathophysiologic basis and technical aspects of DCE-MR imaging techniques.
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