Journal
MAGNETIC RESONANCE IMAGING
Volume 32, Issue 9, Pages 1097-1101Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2014.03.005
Keywords
Bone marrow; Cellularity; MRI; Fat quantification
Funding
- GE Healthcare
- NIH [CA162718]
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The purpose of this study was to evaluate a magnetic resonance imaging (MRI) technique for quantifying the proton density water fraction (PDWF) as a biomarker of bone marrow cellularity. Thirty-six human bone marrow specimens from 18 donors were excised and subjected to different measurements of tissue composition: PDWF quantification using a multiple gradient echo MRI technique, three biochemical assays (triglyceride, total lipid and water content) and a histological assessment of cellularity. Results showed a strong correlation between PDWF and bone marrow cellularity from histology (r = 0.72). A strong correlation was also found between PDWF and the biochemical assay of water content (r = 0.76). These results suggest the PDWF is a predictor of bone marrow cellularity in tissues and can provide a non-invasive assessment of bone marrow changes in clinical patients undergoing radiotherapy. (C) 2014 Published by Elsevier Inc.
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