Journal
MAGNETIC RESONANCE IMAGING
Volume 31, Issue 6, Pages 1012-1016Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2013.01.016
Keywords
Liver; Spine; MRI; Fat fractionSPIO; SPIO
Funding
- GE Healthcare
- Berlex (Bayer)
- NIH [DK075128, CA162718]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (UCSD) [1U01DK061734, 5U01DK061730]
- National Institute of Child Health and Human Development (NICHD)
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This study evaluates the robustness of a magnetic resonance (MR) fat quantification method to changes in R2* caused by an intravenous infusion of superparamagnetic iron oxide (SPIO) contrast agent. The R2* and proton density fat fraction (PDFF) were measured in liver and spine in 14 subjects using an investigational sequence (IDEAL IQ) provided by the MR scanner vendor. Measurements were made before and after SPIO infusion. Results showed SPIO significantly increased R2* in both liver (p = 8.8 x 10(-8)) and spine (p = 13 x 10(-2)) but PDFFs were not significantly different in either the liver (p = 5.5 x 10(-1)) or the spine (p = 5.6 x 10(-1)). These results confirm that the IDEAL IQ method of fat quantification is robust to changes in R2*. Published by Elsevier Inc.
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