Journal
MAGNETIC RESONANCE IMAGING
Volume 28, Issue 8, Pages 1051-1057Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2010.03.021
Keywords
Anticorrelation; Anticorrelations; Default mode; Resting state; Resting; Global regression
Funding
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health [2R01EB000473-08]
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Functional brain imaging studies have identified a set of brain areas typically activated during cognitive tasks (task-positive brain areas) and another set of brain areas typically deactivated during cognitive tasks (task-negative brain areas). Negative correlations, or anticorrelations, between task-positive and task-negative brain areas have been reported at rest. Furthermore, the strength of these anticorrelations appears to be related to cognitive function. However, studies examining anticorrelations have typically employed global regression or similar analysis steps that force anticorrelated relationships to exist between brain areas. Therefore the validity of these findings has been questioned. Here we examine anticorrelations between a task-negative region in the medial frontal gyrus/anterior cingulate cortex and dorsolateral prefrontal cortex, a classic task-positive area, using an analysis that does not include global regression. Instead, we control for whole-brain correlations in the group-level analysis. Using this approach, we demonstrate that the strength of the functional connection between the medial frontal cortex and the dorsolateral prefrontal cortex is related to cognitive function and that this relationship is not an artifact of global regression. (C) 2010 Elsevier Inc. All rights reserved.
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