Journal
MAGNETIC RESONANCE IMAGING
Volume 28, Issue 5, Pages 637-645Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2010.03.001
Keywords
Compressed sensing; Constrained reconstruction; POCS; Total variation; Breast cancer; Dynamic contrast enhanced MRI
Funding
- NIBIB NIH HHS [R01 EB006155, R01 EB006155-03] Funding Source: Medline
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A number of methods using temporal and spatial constraints have been proposed for reconstruction of undersampled dynamic magnetic resonance imaging (MAT) data. The complex data can be constrained or regularized in a number of different ways, for example, the time derivative of the magnitude and phase image voxels can be constrained separately or jointly. Intuitively, the performance of different regularizations will depend on both the data and the chosen temporal constraints. Here, a complex temporal total variation (TV) constraint was compared to the use of separate real and imaginary constraints, and to a magnitude constraint alone. Projection onto Convex Sets (POCS) with a gradient descent method was used to implement the diverse temporal constraints in reconstructions of DCE MRI data. For breast DCE data, serial POCS with separate real and imaginary TV constraints was found to give relatively poor results while serial/parallel POCS with a complex temporal TV constraint and serial POCS with a magnitude-only temporal TV constraint performed well with an acceleration factor as large as R=6. In the tumor area, the best method was found to be parallel POCS with complex temporal TV constraint. This method resulted in estimates for the pharmacokinetic parameters that were linearly correlated to those estimated from the fully-sampled data, with K-trans,K-R=6=0.97 K-trans,K-R=1+0.00 with correlation coefficient r=0.98, k(cp,R=6)=0.95 K-cp,K-R=1+0.00 (r=0.85). These results suggest that it is possible to acquire highly undersampled breast DCE-MRI data with improved spatial and/or temporal resolution with minimal loss of image quality. (C) 2010 Elsevier Inc. All rights reserved.
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