Journal
MAGNETIC RESONANCE IMAGING
Volume 26, Issue 3, Pages 433-435Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2007.08.014
Keywords
exponential decay; T2; diffusion; contrast agents; optimization methods
Funding
- NCI NIH HHS [CA 111911, R01 CA111911] Funding Source: Medline
- NIBIB NIH HHS [R01 EB001015-12, EB 001015, R01 EB001015] Funding Source: Medline
- NINDS NIH HHS [R01 NS050520, NS 050520, R01 NS050520-03, R56 NS050520] Funding Source: Medline
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Estimating the relaxation constant of an exponentially decaying signal from experimental MR data is fundamental in diffusion tensor imaging, fractional anisotropy mapping, measurements of transverse relaxation rates and contrast agent uptake. The precision of such, chi(2) fitting measurements depends on the choice of acquisition parameters made at the design stage of the experiments. In this report of multipoint data is used to demonstrate that the most efficient acquisition strategy is a two-point scheme. We also conjecture that the smallest coefficient of variation of the decay constant achievable in any N-point experiment is 3.6 times larger than that in the image intensity obtained by averaging N acquisitions with minimal exponential weighting. (c) 2008 Elsevier Inc. All rights reserved.
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