Journal
REGENERATIVE MEDICINE
Volume 10, Issue 1, Pages 79-96Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/RME.14.72
Keywords
adipose; adipose-derived stem cells; clinical translation; cluster of differentiation markers; fat grafting; serum-free media; stromal vascular fraction; subpopulation selection
Categories
Funding
- Healing Foundation
- BAAPS (British Association of Aesthetic Plastic Surgeons)
- National Institute for Health Research
- Academy of Medical Sciences
- British Society for Surgery of the Hand
- Academy of Medical Sciences (AMS) [AMS-SGCL7-Reid] Funding Source: researchfish
- National Institute for Health Research [CL-2011-06-004] Funding Source: researchfish
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We have witnessed a rapid expansion of in vitro characterization and differentiation of adipose-derived stem cells, with increasing translation to both in vivo models and a breadth of clinical specialties. However, an appreciation of the truly heterogeneous nature of this unique stem cell group has identified a need to more accurately delineate subpopulations by any of a host of methods, to include functional properties or surface marker expression. Cells selected for improved proliferative, differentiative, angiogenic or ischemia-resistant properties are but a few attributes that could prove beneficial for targeted treatments or therapies. Optimizing cell culture conditions to permit re-introduction to patients is critical for clinical translation.
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