Journal
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
Volume 10, Issue 3, Pages 270-279Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574892810666150617112421
Keywords
Cancer therapeutics; FOXM1; gastric cancer; metastasis; progression; transcription factor
Categories
Funding
- Shanghai Municipal Human Resources and Social Security Bureau [2012040, 13PJD024]
- Shanghai Health and Family Planning Commission [XYQ2013092]
- Shanghai Municipal Science and Technology Commission [144119668]
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The transcription factor FOXM1 is overexpressed in many human cancers, including liver, stomach, prostate, brain, breast, lung, colon, pancreas, cervix, ovary and nervous system. Recent data have demonstrated that FOXM1 is involved in cell initiation, progression, and metastasis and in responses to anticancer drugs. In this review, the effects of FOXM1 on gastric cancer, especially the function and regulation of FOXM1 in tumorigenesis and clinical chemotherapy, will be summarized and discussed together with recent relevant patents on the role of FOXM1 in tumor therapy.
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