Journal
MACROMOLECULAR THEORY AND SIMULATIONS
Volume 19, Issue 8-9, Pages 514-531Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mats.201000033
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Funding
- Marie Curie Reintegration Grant [FP7-PEOPLE-IRG-239471]
- Department of Chemical and Biological Engineering at KOC University
- TUBA-L'OREAL Young Women in Science Award
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The results of a mathematical model for surface-initiated polymerization of biofunctional PEG-based hydrogels to predict gel properties prior to synthesis is reported. The mathematical model developed in this study describes microencapsulation of islets within an insulinotropic peptide (GLP-1) functionalized PEG hydrogels. Experimental measurements of the thickness and swelling of GLP-1 functionalized hydrogel membranes compare well with the model. The model is capable of predicting the crosslink density, thickness, and the level of GLP-1 incorporation within the membrane. This study demonstrates the possibility of modulating the concentration of biological cues in highly permissive and biofunctional PEG hydrogels for optimizing engineered tissue function.
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