Journal
MACROMOLECULAR RESEARCH
Volume 22, Issue 3, Pages 272-278Publisher
POLYMER SOC KOREA
DOI: 10.1007/s13233-014-2036-7
Keywords
myocardial infarction; vascular endothelial growth factor (VEGF); angiogenesis; chitosan hydrogel; theranosis
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Funding
- National Research Foundation of Korea
- Korean Government (Ministry of Education, Science and Technology) [NRF-2009-0078422, NRF-2011-0028581, NRF-2012-M2A2A7035779]
- National R&D Program for Cancer Control, Ministry of Health, Welfare and Family Affairs, Republic of Korea [0620220]
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Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis in an infarcted myocardium. The purpose of the current investigation was to validate whether a radiolabeled VEGF delivery system can be effectively monitored in vivo, and to ascertain whether the growth factor induces an angiogenic effect to facilitate recovery from infarct conditions in rodent myocardial infarction (MI) models. Rat MI models were divided into three groups, one with left anterior descending coronary artery (LAD) ligation with no injection (the control group), one with LAD ligation and I-131 VEGF injection (the VEGF group), and one with LAD ligation and I-131 VEGF-loaded chitosan injection (the VIC group). On day 7 after injection, autoradiography imaging was performed, followed by semiquantitative and histopathologic analyses. In semi-quantitative analysis, the mean anterior-to-inferior wall ratio of the VIC group was significantly higher than those of the control and VEGF groups (p < 0.05). Histopathologic experiments revealed a marked increase in microvascular density in the VIC group compared to those of the control and VEGF groups (p < 0.05). Intramyocardially injected VIC was not only effectively monitored in vivo, but also stimulated therapeutic angiogenesis in the infarcted myocardium. Our findings support that the developed VIC is a novel theranostic tool to improve myocardial perfusion following myocardial infarction.
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