Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 35, Issue 22, Pages 1906-1924Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201400389
Keywords
biocompatible; biodegradable; biomedical applications; glycerol; medicine; polymers
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Funding
- BU, the Nanomedicine Program and Cross-Disciplinary Training in Nanotechnology for Cancer [NIH R25 CA153955]
- BU Nanotheranostics ARC
- National Institute of Health [R01CA149561, R01EY13881]
- National Science Foundation [DMR-1410450]
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Glycerol polymers are attracting increased attention due to the diversity of polymer compositions and architectures available. This article provides a brief chronological review on the current status of these polymers along with representative examples of their use for biomedical applications. First, the underlying chemistry of glycerol that provides access to a range of monomers for subsequent polymerizations is described. Then, the various synthetic methodologies to prepare glycerol-based polymers including polyethers, polycarbonates, polyesters, and so forth are reviewed. Next, several biomedical applications where glycerol polymers are being investigated including carriers for drug delivery, sealants or coatings for tissue repair, and agents possessing antibacterial activity are described. Fourth, the growing market opportunity for the use of polymers in medicine is described. Finally, the findings are concluded and summarized, as well as the potential opportunities for continued research efforts are discussed.
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