Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 35, Issue 6, Pages 649-654Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201300885
Keywords
bioreducible nanoshell; branched polymer; nanoparticle; pH-responsive; temperature-responsive
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Funding
- National Natural Science Foundation of China [51033005, 21074121, 21090354, 21374107]
- Program for New Century Excellent Talents in Universities [NCET-08-0520]
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A new and easy method of stimuli-triggered growth and removal of a bioreducible nanoshell on nanoparticles is reported. The results show that pH or temperature could induce the aggregation of disulfide-contained branched polymers at the surface of nanoparticles; subsequently, the aggregated polymers could undergo intermolecular disulfide exchange to cross-link the aggregated polymers, forming a bioreducible polymer shell around nanoparticles. When these nanoparticles with a polymer shell are treated with glutathione (GSH) or d,l-dithiothreitol (DTT), the polymer shell could be easily removed from the nanoparticles. The potential application of this method is demonstrated by easily growing and removing a bioreducible shell from liposomes, and improvement of in vivo gene transfection activity of liposomes with a bioreducible PEG shell.
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