Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 33, Issue 9, Pages 811-818Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201100876
Keywords
controlled release; core-shell nanoparticles; RAFT polymerization; smart polymers
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Funding
- National Natural Science Foundation of China [20974103, 21074121, 21090354]
- Fundamental Research Funds for the Central Universities [WK 2060200001]
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A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2-(dimethylamino)ethyl methacrylate)-coated MSNs (MSN-PDMAEMA). Subsequently, the tertiary amine groups in PDMAEMA are quaternized with 1,3-propanesultone to get poly(DMAEMA-co-3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)-coated MSNs [MSN-Poly(DMAEMA-co-DMAPS)]. The zwitterionic PDMAPS component endows the nanocarrier with biocompatibility, and the PDMAEMA component makes the copolymer shell temperature-responsive. Controlled release of loaded rhodamine B has been achieved in the saline solutions.
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