Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 34, Issue 2, Pages 142-149Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201200524
Keywords
alginate; cell imprinting; hybrid scaffold; polycaprolactone; tissue engineering
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A new cell-printed scaffold consisting of poly(epsilon-caprolactone) (PCL) and cell-embedded alginate struts is designed. The PCL and alginate struts are stacked in an interdigitated pattern in successive layers to acquire a three-dimensional (3D) shape. The hybrid scaffold exhibits a two-phase structure consisting of cell (MC3T3-E1)-laden alginate struts able to support biological activity and PCL struts able to provide controllable mechanical support of the cell-laden alginate struts. The hybrid scaffolds exhibit an impressive increase in tensile modulus and maximum strength compared to pure alginate scaffolds. Laden cells are homogeneously distributed throughout the alginate struts and the entire scaffold, resulting in cell viability of approximately 84%.
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