Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 32, Issue 14, Pages 1082-1089Publisher
WILEY-BLACKWELL
DOI: 10.1002/marc.201100198
Keywords
charge conversion polymers; drug delivery systems; mesoporous silica nanoparticles (MSN); polyelectrolytes; layer-by-layer (LBL) deposition
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Funding
- National Natural Scientific Foundation of China (NNSFC) [20874092, 91027026, 51033005]
- Fundamental Research Funds for the Central Universities
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
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We report on the fabrication of pH-disintegrable polyelectrolyte multilayer-coated mesoporous silica nanoparticles (MSN) capable of triggered co-release of cisplatin and model drug molecules. The outer polyelectrolyte multilayer was assembled from permanently cationic polyelectrolyte, poly(allyl amine hydrochloride) (PAH), and negatively charged polyelectrolyte, P(DMA-co-TPAMA), consisting of N,N-dimethylacrylamide (DMA) and 3,4,5,6-tetrahydrophthalic anhydride-functionalized N-(3-aminopropyl)methacrylamide (TPAMA) monomer units, which exhibits pH-induced charge conversion characteristics. Thus, the subtle alteration of solution pH from 7.4 to approximate to 5-6 can lead to the disintegration of outer polyelectrolyte multilayers, accompanied with the co-release of cisplatin and RhB.
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