Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 31, Issue 17, Pages 1516-1520Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201000112
Keywords
core-shell polymers; drug delivery systems; supramolecular host-guest interaction; hyperbranched polyglycerol
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Funding
- Bundesministerium fur Bildung und Forschung
- German Science Foundation (DFG)
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Dendritic core-shell architectures which are based on hyperbranched polyglycerol for the solubilization of hydrophobic drugs have been synthesized and characterized. The core of hyperbranched polyglycerol has been modified with hydrophobic biphenyl groups or perfluorinated chains to increase the core hydrophobicity of the macromolecules. These amphiphilic core-shell type architectures were then used to solubilize pyrene, nile red, and a perfluoro tagged diazo dye, as well as the drug nimodipine in water. Specific host-guest interactions such as fluorous-fluorous interactions could be tailored by this flexible core design and determined by UV spectroscopy. The transport capacity increased 450-fold for nile red, 47-fold for nimodipine, and 37-fold for pyrene at a polymer concentration of only 0.1 wt.-%. Surface tension measurements and scanning force microscopy (SFM) were used to reveal the aggregation properties of these complexes. The formation of supramolecular aggregates with diameters of approximate to 20 nm and critical aggregate concentrations of 2 x 10(-6) mol . L-1 have been observed. This indicates the controlled self-assembly of the presented amphiphilic dendritic core-shell type architectures.
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