Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 31, Issue 17, Pages 1492-1500Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201000090
Keywords
biocompatible block copolymers; chain; fluorescence correlation spectroscopy; HPMA block copolymers; polylactide block copolymers; RAFT polymerization; synthesis
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Funding
- School of excellence MAINZ
- COMATT
- IMPRS
- Spanish Ministry [CTQ2007-60601]
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We describe a synthetic pathway to functional P(HPMA)-b-P(LLA) block copolymers. The synthesis relies on a combination of ring-opening polymerization of L-lactide, conversion into a chain transfer agent (CTA) for the RAFT polymerization of pentafluorophenyl methacrylate. A series of block copolymers was prepared that exhibited molecular weights (M) over bar (n) ranging from 7 600 to 34 300 g . mol(-1), with moderate PDI between 1.3 and 1.45. These reactive precursor polymers have been transformed into biocompatible P(HPMA)-b-P(LLA) copolymers and their fluorescently labeled derivatives by facile replacement of the pentafluorophenyl groups. The fluorescence label attached to this new type of a partially degradable amphiphilic block copolymer was used to study cellular uptake in human cervix adenocarcinoma (HeLa) cells as well as aggregation behavior by fluorescence correlation spectroscopy (FCS).
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