Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 31, Issue 17, Pages 1534-1539Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201000274
Keywords
biomaterials; gelatin; molecular modeling; polymer analogous reaction; supramolecular interaction
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB 760, B5]
Ask authors/readers for more resources
Molecular models of gelatin-based materials formed the basis for the knowledge-based design of a physically cross-linked polymer system. The computational models with 25 wt.-% water content were validated by comparison of the calculated structural properties with experimental data and were then used as predictive tools to study chain organization, cross-link formation, and estimation of mechanical properties. The introduced tyrosine-derived side groups, desaminotyrosine (DAT) and desaminotyrosyl tyrosine (DATT), led to the reduction of the residual helical conformation and to the formation of physical net-points by pi-pi interactions and hydrogen bonds. At 25 wt.-% water content, the simulated and experimentally determined mechanical properties were in the same order of magnitude. The degree of swelling in water decreased with increasing the number of inserted aromatic functions, while Young's modulus, elongation at break, and maximum tensile strength increased.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available