Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 32, Issue 4, Pages 390-396Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201000600
Keywords
drug delivery system; hyperbranched polycarbonate; micelles; PEGylation; self-condensing ring-opening polymerization
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Funding
- National Natural Science Foundation of China [20874075]
- National Key Basic Research Program of China [2005CB623903, 2009CB930301]
- Ministry of Education of China [707043]
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We herein develop a facile catalyst-free method to prepare hyperbranched hydroxyl-enriched aliphatic polycarbonate according to SCROP strategy. PEG-attached multiarm hyperbranched copolymer HEHDO-star-mPEG was further designed. It was found that HEHDO-star-mPEG can self-assemble into supramolecular multimolecular micelles in water. HEHDO-star-mPEG micelle showed excellent stability with respect to micellar size upon dilution, and displayed good cell-biocompatibility. An anticancer drug of doxorubicin with hydrogen-bonding functionality was incorporated into obtained micelles to establish a drug delivery system model. A high drug-loading content as well as sustained release pattern for HEHDO-star-mPEG based delivery system was achieved.
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