Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 30, Issue 9-10, Pages 845-850Publisher
WILEY-BLACKWELL
DOI: 10.1002/marc.200800744
Keywords
biomaterials and biological applications of polymers; peptides; ring-opening polymerization; surfaces
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Funding
- China Scholarship Council
- National Construction of high-quality University
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This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anchored polypeptide chains assume an a-helical conformation, which does not change between pH 4 and 9. Furthermore, nonspecific adsorption of fluorescent labeled bovine serum albumin and fibrinogen on glass slides modified with these brushes was greatly reduced compared to unmodified glass substrates.
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