Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 29, Issue 19, Pages 1577-1581Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200800277
Keywords
biomaterials; mechanical properties; poly(epsilon-caprolactone); scaffold; tissue engineering
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Funding
- National Research Foundation of Korea [2008-04224] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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An ideal scaffold should have good mechanical properties and provide a biologically functional implant site. A rapid prototyping system has been introduced as a good method of fabricating 3D scaffolds that mimic the structure in the human body. However, the scaffolds have strands that are too smooth and a pore size that is too large relative to the seeded cells and present unfavorable conditions for initial cell attachment. To overcome these problems, we propose a hybrid technology combining a 3D rapid prototyping system and an electrospinning process to produce a hierarchical 3D biomedical scaffold. The resulting structure consists of alternating layers of 3D-structured/microsized polymer strands and nanofiber webs. The results of cell culturing of chondrocytes indicate that this technique is a feasible new method for fabricating high quality 3D polymeric scaffolds.
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