Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 29, Issue 22, Pages 1810-1816Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200800494
Keywords
hydrophilic polymers; pH responsive; polypeptide; self-assembly; temperature responsive
Categories
Funding
- National Natural Science Foundation of China [50573078, 50733003, 20621140369]
- National Fund for Distinguished Young Scholar [50425309]
- Ministry of Science and Technology of China [2007DFR5020]
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A series of novel temperature and pH responsive block copolymers composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(L-lysine) (PLL) were synthesized. The effect of pH and the length of PLL on the lower critical solution temperature (LCST) of PNIPAM, and the self-assembly of these PLL-based copolymers induced by temperature and pH changes were investigated by the cloud point method, dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). These PNIPAM-b-PLL copolymers can self-assemble into micelle-like aggregates with PNIPAM as the hydrophobic block at acidic pH and high temperatures; and at alkaline pH and low hey can self-assemble into temperatures, particles with PLL as the hydrophobic block. The copolymers may have potential applications in biotechnological and biomedical areas as drug release carriers.
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