Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 29, Issue 2, Pages 123-129Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.200700663
Keywords
acid-degradable; crosslinked micelle; glycopolymer; reversible addition fragmentation chain transfer (RAFT); stimuli-sensitive polymers
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A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA(180)-b-PNIPAAM(350))was simultaneously self-assembled and cross-linked in aqueous medium via RAFT polymerization at 60 degrees C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against crosslinked micelles readily hydrolyzed block copolymers at lower pH (30 min and 12 h respectively pH = 2 and 4).
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