Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 214, Issue 24, Pages 2875-2881Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201300579
Keywords
diselenide; drug delivery nanocarriers; oxidation-responsive cleavage; post-assembly; stimuli-responsive amphiphilic block polymers
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Funding
- National High-tech Research and Development Projects (863) [2013AA06A306]
- National Natural Science Foundation of China [20874102]
- Sichuan Province Science and Technology Support Projects [2010FZ0093]
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Linear amphiphilic triblock polymers containing a single diselenide (SeSe-tri-ABP) are synthesized by coupling reactions. They self-assemble into spherical micelles 1 in aqueous solution. A remarkable morphology transformation of the micelles is confirmed through dynamic light scattering (DLS) and transmission electron microscopy (TEM). The release behavior of a model molecule, Rhodamine B (RB), is studied by UV-vis spectrophotometry. It is found that post-assembly from micelles 1 to micelles 2 is induced by the oxidation-responsive cleavage of the diselenide group in the oxidation solution. Interestingly, the RB release studies reveal that these micelles release RB in a diphasic pattern (slow after initial fast release) within 24 h under an oxidative environment. In contrast, minimal drug release (<20%) is observed within 24 h for SeSe-tri-ABP micelles under aqueous conditions. Meanwhile, this release behavior of the RB-loaded micelles can be tuned by the post-assembly of oxidation-responsive SeSe-tri-ABP in different oxidation conditions, providing a promising platform for controlled delivery of nanocarriers.
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