High Intensity Focused Ultrasound Triggered Shape Memory and Drug Release from Biodegradable Polyurethane

A shape memory biodegradable polyurethane composite is prepared and shape recovery and simultaneous release of embedded copper sulfate are realized by high intensity focused ultrasound (HIFU). The composite shows an excellent HIFU-controlled shape recovery performance, wherein temporal and spatial control can be realized by switching the HIFU on/off or selecting the place where the ultrasound is focused. The composite shows an excellent HIFU switchable drug release function. The release process of a model payload can be tuned by adjusting the HIFU intensity and time. The shape memory polyurethane shows a rapid enzymatic biodegradation rate. This polyurethane composite has potential applications in minimally invasive interventional therapy devices.