Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 214, Issue 11, Pages 1204-1214Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201200342
Keywords
actuation rate; biomaterials; hydrophobicity; polyurethanes; shape-memory foams
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Funding
- US Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]
- National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering [R01-EB000462]
- Lawrence Livermore National Laboratory Directed Research and Development (LDRD) [04-LW-054, 04-ERD-093]
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SMPs have been shown to actuate below their dry glass transition temperatures in the presence of moisture due to plasticization. This behavior has been proposed as a self-actuating mechanism of SMPs in water/physiological media. However, control over the SMP actuation rate, a critical factor for in vivo transcatheter device delivery applications, has not been previously reported. Here, a series of polyurethane SMPs with systematically varied hydrophobicity is described that permits control of the time for their complete shape recovery in water from under 2 min to more than 24 h. This control over the SMP actuation rate can potentially provide significant improvement in their delivery under conditions, which may expose them to high-moisture environments prior to actuation.
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