Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 213, Issue 2, Pages 215-226Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201100388
Keywords
crosslinking; electron beam irradiation; micelles; stimuli-sensitive polymers; nanoparticles
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Funding
- Deutscher Akademischer Austauschdienst (DAAD)
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Amphiphilic graft copolymers with a thermosensitive PNiPAAm backbone and pH-sensitive hydrophilic poly(2-carboxyethyl-2-oxazoline) graft chains are synthesized. In aqueous solution, stable micelle-like aggregates are formed by increasing the temperature in the pH range 4.55.5. The micelles are crosslinked by electron-beam irradiation, yielding stable coreshell nanogels of about 100 nm diameter with reversible thermo- and pH-dependent swelling behavior. The temperature sensitivity is provided by a conformational change in the PNiPAAm core, whereas the thickness of the poly(2-carboxyethyl-2- oxazoline) corona depends on pH. The reversible bisensitivity of core-crosslinked nanogels is verified by DLS, while AFM measurements demonstrate the predicted coreshell structures of the aggregates.
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