Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 212, Issue 20, Pages 2268-2274Publisher
WILEY-BLACKWELL
DOI: 10.1002/macp.201100352
Keywords
light scattering; pH-responsive materials; protein mimics; polyampholytes; stimuli-responsive polymers
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Funding
- National Natural Science Foundation of China [21074005, 20990232]
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As a mimic of protein, a polyampholyte-based material should be able to duplicate the properties and functions of protein. A polyampholyte that is highly sensitive to both pH and temperature under physiological conditions is obtained when 80% butylamide-terminated poly(amidoamine) dentron is grafted to the backbone of styrene and maleic anhydride. The phase separation occurs at 33.7 degrees C at pH = 6.20, while the transition point increases to 43.9 degrees C at pH = 6.30. The superior performance is the consequence of the cooperative interactions among basic, acidic, and thermoresponsive groups. The polyampholyte with a suitable isoelectric point provides a platform for the development of multifunctional materials for biomedical applications.
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